Clobetasol propionate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

丙酸氯倍他索是一种抗炎皮质类固醇，用于治疗各种皮肤病。

Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.(In Vitro):Clobetasol propionate has an IC50 of 15.6 μM for CYP3A4.Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1CYP3A5–/– cells with CYP3A5 overexpression (“3A5–/– + 3A5OE” cells), and AsPC-1CYP3A5–/– cells with CYP3A4 overexpression (“3A5–/– + 3A4OE” cells)).(In Vivo):Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application.

Clobetasol propionate has an IC50 of 15.6 μM for CYP3A4.Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1CYP3A5–/– cells with CYP3A5 overexpression (“3A5–/– + 3A5OE” cells), and AsPC-1CYP3A5–/– cells with CYP3A4 overexpression (“3A5–/– + 3A4OE” cells)).

Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application.

CCl-4725 | CGP 9555 | Clobetasol 17-Propionate

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Inflammation/Immunology

——

25122-46-7

466.97

C25H32ClFO5

>98% (HPLC)

Ethanol: 20 mg/mL (42.82 mM); DMSO: 93 mg/mL (199.15 mM)

CCC(O[C@]1(C)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C(CCl)=O)=O)=O

(8S,9R,10S,11S,13R,14S,16S,17R)-13-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,16,17-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

(-20℃)

With Ice Pack

≥ 2 years